abstract：INTRODUCTION:Mesenchymal stem cells (MSCs) can differentiate into various connective tissue cells. Several techniques have been used for the clinical application of MSCs in articular cartilage repair; however, there are many issues associated with the selection of the scaffold material, including its ability to support...

journal_title：Arthritis research & therapy

authors： Sato M,Uchida K,Nakajima H,Miyazaki T,Guerrero AR,Watanabe S,Roberts S,Baba H

更新日期：2012-02-07 00:00:00

abstract：:Glucosamine in its acetylated form is a natural constituent of some glycosaminoglycans (for example, hyaluronic acid and keratan sulfate) in the proteoglycans found in articular cartilage, intervertebral disc and synovial fluid. Glucosamine can be extracted and stabilized by chemical modification and used as a drug or...

journal_title：Arthritis research & therapy

authors： Henrotin Y,Mobasheri A,Marty M

更新日期：2012-01-30 00:00:00

abstract：INTRODUCTION:Protein citrullination is present in the rheumatoid synovium, presumably contributing to the perpetuation of chronic inflammation, in the presence of specific autoimmunity. As a result, the present study examined the possibility that effective antirheumatic treatment will decrease the level of synovial cit...

journal_title：Arthritis research & therapy

authors： Makrygiannakis D,Revu S,Engström M,af Klint E,Nicholas AP,Pruijn GJ,Catrina AI

更新日期：2012-01-27 00:00:00

abstract：INTRODUCTION:Cartilage oligomeric matrix protein (COMP) is found at elevated concentrations in sera of patients with joint diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). We recently showed that COMP activates complement via the alternative pathway and that COMP-C3b complexes are present in sera of ...

journal_title：Arthritis research & therapy

authors： Happonen KE,Saxne T,Geborek P,Andersson M,Bengtsson AA,Hesselstrand R,Heinegård D,Blom AM

更新日期：2012-01-20 00:00:00

abstract：INTRODUCTION:Bone marrow lesions (BMLs) play an important role in knee osteoarthritis, but their etiology is not well understood. The aim of this longitudinal study was to describe the association between dietary factors, serum lipids, and BMLs. METHODS:In total, 394 older men and women (mean age, 63 years; range, 52 ...

journal_title：Arthritis research & therapy

authors： Doré D,de Hoog J,Giles G,Ding C,Cicuttini F,Jones G

更新日期：2012-01-18 00:00:00

abstract：INTRODUCTION:Pateclizumab (MLTA3698A) is a humanized mAb against lymphotoxin α (LTα), a transiently expressed cytokine on activated B and T cells (Th1, Th17), which are implicated in rheumatoid arthritis (RA) pathogenesis. This study was conducted to assess the safety, tolerability, < NOTE: For clarity and per AMA/S-W ...

journal_title：Arthritis research & therapy

authors： Emu B,Luca D,Offutt C,Grogan JL,Rojkovich B,Williams MB,Tang MT,Xiao J,Lee JH,Davis JC

更新日期：2012-01-08 00:00:00

abstract：INTRODUCTION:Osteoarthritis (OA) is a degenerative disease characterized by cartilage breakdown in the synovial joints. The presence of low-grade inflammation in OA joints is receiving increasing attention, with synovitis shown to be present even in the early stages of the disease. How the synovial inflammation arises ...

journal_title：Arthritis research & therapy

authors： Sohn DH,Sokolove J,Sharpe O,Erhart JC,Chandra PE,Lahey LJ,Lindstrom TM,Hwang I,Boyer KA,Andriacchi TP,Robinson WH

更新日期：2012-01-08 00:00:00

abstract：INTRODUCTION:Systemic lupus erythematosus (SLE) is a chronic autoimmune disease. Cardiovascular disease (CVD) is common and a major cause of mortality. Studies on cardiovascular morbidity are abundant, whereas mortality studies focusing on cardiovascular outcomes are scarce. The aim of this study was to investigate cau...

journal_title：Arthritis research & therapy

authors： Gustafsson JT,Simard JF,Gunnarsson I,Elvin K,Lundberg IE,Hansson LO,Larsson A,Svenungsson E

更新日期：2012-01-01 00:00:00

abstract：:Susceptibility for giant cell arteritis increases with chronological age, in parallel with age-related restructuring of the immune system and age-induced remodeling of the vascular wall. Immunosenescence results in shrinkage of the naïve T-cell pool, contraction of T-cell diversity, and impairment of innate immunity. ...

journal_title：Arthritis research & therapy

authors： Mohan SV,Liao YJ,Kim JW,Goronzy JJ,Weyand CM

更新日期：2011-08-02 00:00:00

abstract：:Interstitial lung disease is a common manifestation of autoimmune myositis that confers significant morbidity and mortality. The vulnerability of the lung may offer insight into the etiology of this autoimmune disease. The frequency and patterns of lung injury vary based on the autoantibody. Antibodies against the ami...

journal_title：Arthritis research & therapy

authors： Danoff SK,Casciola-Rosen L

更新日期：2011-07-13 00:00:00

abstract：:The difficulty in predicting the consequences of interactions between different cytokine networks has increased with the expansion of the T helper (Th) cell universe and the discovery of numerous B lymphocyte-derived cytokines. Consequently, it is now difficult to conceptualize a straightforward view of the contributi...

journal_title：Arthritis research & therapy

authors： Youinou P,Pers JO

更新日期：2011-07-06 00:00:00

abstract：:Pulmonary involvement is a common complication of vasculitides, especially small vessel vasculitides. This review provides an overview of vasculitic manifestations of the lung as well as of other organs involved in vasculitides. Furthermore, it provides the diagnostic procedures required to asses a patient with vascul...

journal_title：Arthritis research & therapy

authors： Holle JU,Moosig F,Dalhoff K,Gross WL

更新日期：2011-06-30 00:00:00

abstract：INTRODUCTION:Immunological studies of giant cell arteritis (GCA) suggest that a triggering antigen of unknown nature could generate a specific immune response. We thus decided to detect autoantibodies directed against endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) in the serum of GCA patients and to i...

journal_title：Arthritis research & therapy

authors： Régent A,Dib H,Ly KH,Agard C,Tamby MC,Tamas N,Weksler B,Federici C,Broussard C,Guillevin L,Mouthon L

更新日期：2011-06-28 00:00:00

abstract：INTRODUCTION:In this study, we aimed to determine the relationship between flow-mediated endothelium-dependent vasodilatation (FMD) and carotid artery intima-media wall thickness (IMT), two surrogate markers of atherosclerosis, in a series of Spanish patients with rheumatoid arthritis (RA) without clinically evident ca...

journal_title：Arthritis research & therapy

authors： González-Juanatey C,Llorca J,González-Gay MA

更新日期：2011-06-22 00:00:00

abstract：:Recent genome-wide association studies have advanced our understanding of genetic factors that underlie systemic lupus erythematosus (SLE), a multifactorial autoimmune disease characterized by various clinical manifestations. SLE also has an environmental component, which can trigger or exacerbate the disease. Despite...

journal_title：Arthritis research & therapy

authors： Koike T

更新日期：2011-05-31 00:00:00

abstract：INTRODUCTION:The translational and predictive value of animal models highly depends on the validity of respective readout parameters. In arthritis research, there has been a shift from sole threshold testing for pain-related behavior, as well as from swelling and histology assessment for inflammation, toward an analysi...

journal_title：Arthritis research & therapy

authors： Boettger MK,Leuchtweis J,Schaible HG,Schmidt M

更新日期：2011-05-27 00:00:00

abstract：:It has long been recognized that laboratory tests are useful in the diagnosis of disease and to monitor treatment outcome. Their performance has become even more demanding with the development of personalized medicine. In patients with rheumatoid arthritis (RA) the standard biochemical tests measure serological marker...

journal_title：Arthritis research & therapy

authors： van de Loo FA

更新日期：2011-04-27 00:00:00

abstract：INTRODUCTION:The objective of this study is to determine if multiple systemic autoimmune diseases (SAID) share gene expression pathways that could provide insights into pathogenic mechanisms common to these disorders. METHODS:RNA microarray analyses (Agilent Human 1A(V2) 20K oligo arrays) were used to quantify gene ex...

journal_title：Arthritis research & therapy

authors： O'Hanlon TP,Rider LG,Gan L,Fannin R,Paules RS,Umbach DM,Weinberg CR,Shah RR,Mav D,Gourley MF,Miller FW

更新日期：2011-04-26 00:00:00

abstract：INTRODUCTION:A number of genetic-association studies have identified genes contributing to ankylosing spondylitis (AS) susceptibility but such approaches provide little information as to the gene activity changes occurring during the disease process. Transcriptional profiling generates a 'snapshot' of the sampled cells...

journal_title：Arthritis research & therapy

authors： Pimentel-Santos FM,Ligeiro D,Matos M,Mourão AF,Costa J,Santos H,Barcelos A,Godinho F,Pinto P,Cruz M,Fonseca JE,Guedes-Pinto H,Branco JC,Brown MA,Thomas GP

更新日期：2011-04-07 00:00:00

abstract：:Autoantibodies targeting intracellular proteins involved in key processes are detected in patients with idiopathic inflammatory myopathies. These myositis-specific autoantibodies have been increasingly demonstrated to correlate with distinct clinical phenotypes within the myositis spectrum. This review highlights the ...

journal_title：Arthritis research & therapy

authors： Betteridge ZE,Gunawardena H,McHugh NJ

更新日期：2011-03-18 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease resulting from a loss of tolerance to multiple self antigens, and characterized by autoantibody production and inflammatory cell infiltration in target organs, such as the kidneys and brain. T cells are critical players in SLE pathophysiology as they regulate...

journal_title：Arthritis research & therapy

authors： Moulton VR,Tsokos GC

更新日期：2011-03-17 00:00:00

abstract：:Historically, pregnancy in women with many inflammatory rheumatic diseases was not considered safe and was discouraged. Combined care allows these pregnancies to be managed optimally, with the majority of outcomes being favorable. Disease activity at the time of conception and anti-phospholipid antibodies are responsi...

journal_title：Arthritis research & therapy

authors： Jain V,Gordon C

更新日期：2011-02-25 00:00:00

abstract：INTRODUCTION:We and others have previously shown that antibodies against cyclic citrullinated proteins (anti-CCP) precede the development of rheumatoid arthritis (RA) and in a more recent study we reported that individuals who subsequently developed RA had increased concentrations of several cytokines and chemokines ye...

journal_title：Arthritis research & therapy

authors： Kokkonen H,Mullazehi M,Berglin E,Hallmans G,Wadell G,Rönnelid J,Rantapää-Dahlqvist S

更新日期：2011-02-03 00:00:00

abstract：:Genomewide association studies (GWAS) have proven a powerful hypothesis-free method to identify common disease-associated variants. Even quite large GWAS, however, have only at best identified moderate proportions of the genetic variants contributing to disease heritability. To provide cost-effective genotyping of com...

journal_title：Arthritis research & therapy

authors： Cortes A,Brown MA

更新日期：2011-02-01 00:00:00

abstract：INTRODUCTION:Rheumatic diseases are among the most common and debilitating health problems in the United States. These diseases are chronic, can result in severe decrements of physical and psychosocial functioning and affect patients' overall quality of life. A consensus regarding the best patient outcomes to be measur...

journal_title：Arthritis research & therapy

authors： Wallen GR,Middleton KR,Rivera-Goba MV,Mittleman BB

更新日期：2011-01-05 00:00:00

abstract：INTRODUCTION:The revised shared epitope (SE) concept in rheumatoid arthritis (RA) is based on the presence (S) or absence (X) of the SE RAA amino acid motif at positions 72 to 74 of the third hypervariable region of the various human leucocyte antigen (HLA)-DRB1 alleles. The purpose of this study was to investigate SE ...

journal_title：Arthritis research & therapy

authors： Meyer PW,Hodkinson B,Ally M,Musenge E,Wadee AA,Fickl H,Tikly M,Anderson R

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Systemic lupus erythematosus (SLE) patients have lower bone mineral density and increased fracture risk when compared with healthy individuals, due to distinct factors and mechanisms. Bone remodeling is a tightly orchestrated process dependent on several factors, including the balance between receptor acti...

journal_title：Arthritis research & therapy

authors： Carmona-Fernandes D,Santos MJ,Perpétuo IP,Fonseca JE,Canhão H

更新日期：2011-01-01 00:00:00

abstract：:I comment on the well-designed trial by Alda and colleagues reported in a recent issue of Arthritis Research and Therapy which demonstrated some benefits of cognitive-behavioral therapy (CBT) for fibromyalgia (FM). CBT in this and other studies provides statistically significant but rather modest benefits for FM. This...

journal_title：Arthritis research & therapy

authors： Lumley MA

更新日期：2011-01-01 00:00:00

abstract：:Treatment of Sjögren's syndrome is almost entirely symptomatic. A lack of true understanding of the underlying immunological pathology of the disease prevents directed therapy. Interleukin-21 (IL-21) is elevated in the serum of patients with this disease and is expressed by the lymphocytes infiltrating the salivary gl...

journal_title：Arthritis research & therapy

authors： Scofield RH

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:The purpose of this study was to examine data from the Johnston County Osteoarthritis (OA) Project for independent associations of educational attainment, occupation and community poverty with tibiofemoral knee OA. METHODS:A cross-sectional analysis was conducted on 3,591 individuals (66% Caucasian and 34...

journal_title：Arthritis research & therapy

authors： Callahan LF,Cleveland RJ,Shreffler J,Schwartz TA,Schoster B,Randolph R,Renner JB,Jordan JM

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:The present study examined the effect of C-type natriuretic peptide (CNP) on the anabolic and catabolic activities in chondrocyte/agarose constructs subjected to dynamic compression. METHODS:Constructs were cultured under free-swelling conditions or subjected to dynamic compression with low (0.1 to 100 pM...

journal_title：Arthritis research & therapy

authors： Ramachandran M,Achan P,Salter DM,Bader DL,Chowdhury TT

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Chronic inflammation is a profound systemic modification of the cellular microenvironment which could affect survival, repair and maintenance of muscle stem cells. The aim of this study was to define the role of chronic inflammation on the regenerative potential of satellite cells in human muscle. METHODS...

journal_title：Arthritis research & therapy

authors： Duijnisveld BJ,Bigot A,Beenakker KG,Portilho DM,Raz V,van der Heide HJ,Visser CP,Chaouch S,Mamchaoui K,Westendorp RG,Mouly V,Butler-Browne GS,Nelissen RG,Maier AB

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Rheumatoid arthritis (RA) is considered a T cell driven autoimmune disease, therefore, the ability of B cell depleting biologics, e.g., anti-CD20 antibodies, to alleviate RA is unclear. This study examined the proportions of IL-17-secreting lymphocytes in the blood of healthy subjects and RA patients and d...

journal_title：Arthritis research & therapy

authors： Eggleton P,Bremer E,Tarr JM,de Bruyn M,Helfrich W,Kendall A,Haigh RC,Viner NJ,Winyard PG

更新日期：2011-01-01 00:00:00

abstract：:There is increasing recognition that central pain sensitivity plays an important role in pain severity among patients with osteoarthritis. Murphy and colleagues identified clusters of patients with osteoarthritis according to pain severity and accompanying symptoms, and one of these groups appeared to have a greater d...

journal_title：Arthritis research & therapy

authors： Allen K

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Studies investigating genetic risk factors for susceptibility to rheumatoid arthritis (RA) studied anti-citrullinated peptide antibody (CCP)-positive RA more frequently than anti-CCP-negative RA. One of the reasons for this is the perception that anti-CCP-negative RA may include patients that fulfilled cri...

journal_title：Arthritis research & therapy

authors： De Rooy DP,Willemze A,Mertens B,Huizinga TW,Van der Helm-van Mil AH

更新日期：2011-01-01 00:00:00

abstract：:Systemic lupus erythematosus is a prototypic autoimmune disease characterized by autoantibody production and immune complex formation/deposition in target organs such as the kidney. Resultant local inflammation then leads to organ damage. Nephritis, a major cause of morbidity and mortality in patients with lupus, occu...

journal_title：Arthritis research & therapy

authors： Nowling TK,Gilkeson GS

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:IL-10 is a very important anti-inflammatory cytokine. However, the role of this cytokine in T cells in the pathogenesis of collagen-induced arthritis is unclear. The purpose of this study was to define the role of IL-10 signaling in T cells in the pathogenesis of collagen-induced arthritis. METHODS:IL-10 ...

journal_title：Arthritis research & therapy

authors： Tao J,Kamanaka M,Hao J,Hao Z,Jiang X,Craft JE,Flavell RA,Wu Z,Hong Z,Zhao L,Yin Z

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Human cytomegalovirus (HCMV) infection has been implicated in the development of autoimmunity, including systemic lupus erythematosus (SLE). Previously we reported that HCMV phosphoprotein 65 (pp65) could induce early onset of autoantibody and glomerulonephritis on lupus-prone NZB/W mice. This study furthe...

journal_title：Arthritis research & therapy

authors： Hsieh AH,Jhou YJ,Liang CT,Chang M,Wang SL

更新日期：2011-01-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that is known to be associated with polyclonal B-cell hyperreactivity. The underlying causes of the diffuse B-cell over-reactivity are unclear, but potential candidates include (a) intrinsic hyper-reactivity leading to polyclonal B-cell activation wit...

journal_title：Arthritis research & therapy

authors： Dörner T,Giesecke C,Lipsky PE

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Cardiovascular disease (CVD) is the leading cause of death in patients with inflammatory polyarthritis (IP), especially in seropositive disease. In established rheumatoid arthritis (RA), insulin resistance (IR) is increased and associated with CVD. We investigated factors associated with IR in an inception...

journal_title：Arthritis research & therapy

authors： Mirjafari H,Farragher TM,Verstappen SM,Yates A,Bunn D,Marshall T,Lunt M,Symmons DP,Bruce IN

更新日期：2011-01-01 00:00:00